Jesuit Missions (UNESCO World Heritage), La Santísima Trinidad and Jesús de Tavarangué are among South America's best Spanish-Jesuit colonial ruins (1706–1768). Located in Encarnación region (south Paraguay, 30 minutes apart). Highlights: red-stone churches, school complexes, Guaraní-Christian fusion sculptures (the iconic Mary statues in Guaraní style), excellent preservation. $10/person park entry covers both sites. Plan 1 day from Encarnación. Combine with: San Cosme y Damián (third Jesuit mission in same area). Best months: April–October.
Iguazú Falls access (3-country triangle border), Paraguay's Ciudad del Este is at the Triple Frontier (Brazil/Argentina/Paraguay) where the Paraná and Iguazú rivers meet. Cross to Brazilian side (Foz do Iguaçu) for sweeping panoramic views, 30 minutes by taxi over Friendship Bridge. Cross to Argentine side (Puerto Iguazú) for closer encounters with Devil's Throat, 1 hour by taxi over Tancredo Neves Bridge. Many Paraguayan travelers stay in Ciudad del Este (cheaper accommodations) and day-trip to both falls sides. Plan 2–3 nights at Ciudad del Este or Foz do Iguaçu (Brazil side typically preferred for accommodations).
Asunción, colonial-era capital. Highlights: Plaza de los Héroes (with Panteón Nacional de los Héroes, pantheon of the country's military heroes, Brazilian War 1864–1870 dead), Palacio de los López (presidential palace, gorgeous riverside), Manzana de la Rivera (cultural complex), Casa de la Independencia (1772, where independence was declared 1811), Catedral Metropolitana. Restaurant scene: chipa (the country's iconic cassava-and-cheese bread), sopa paraguaya (cornbread, the only solid 'soup' in the world), asado (grilled meats). Plan 2 nights.
Itaipu Dam, the world's second-largest hydroelectric facility (after China's Three Gorges); generates 75% of Paraguay's electricity and 17% of Brazil's. Visit the technical tour ($25/person), 1.5 hours including dam interior, viewpoints. Reach via Ciudad del Este (10 minutes). Plan half-day.
Gran Chaco, Paraguay's vast western wilderness (the country's 60% of land area but only 3% of population). Filadelfia is the iconic Mennonite colony (founded 1930s by German Mennonite refugees who built thriving agricultural communities in the harsh Chaco, German still spoken, traditional dress, Mennonite restaurants). Indigenous Ayoreo people in remote communities. Defensores del Chaco National Park (jaguars, peccaries, giant armadillos). Reach via: 8-hour drive from Asunción. Best months: April–October (winter, Chaco summer temperatures over 45°C are dangerous). Plan 3–5 nights.
Caacupé (60 km from Asunción), Basilica of the Virgin of Caacupé, the country's most important Catholic pilgrimage site. Día de la Virgen de Caacupé (December 8) brings 500,000+ pilgrims. Plan half-day.
San Bernardino, lakeside resort town near Asunción (1 hour). Lake Ypacaraí. Popular Asunción weekend escape. Plan 1–2 nights.
Concepción, colonial Río Paraguay city. River cruises north to Pantanal wetland edges. Plan 2 nights.
A clean two-week structure: 3 nights Asunción → 2 nights Encarnación (Jesuit Missions) → 3 nights Ciudad del Este (Itaipu Dam, both Iguazú Falls sides) → 4 nights Gran Chaco (Filadelfia + Defensores del Chaco) → 2 nights Asunción return.